Patients who will undergo pancreatectomy
Conditions
Interventions
Pancrelipase group: 600mg of pancrelipase to be taken three times a day (1800mg /day) after meals for 24weeks.
Pancreatin group: One gram of pancreatin to be taken three times a day (3g /day) after
Sponsors
Chiba University, Graduate School of Medicine, Department of General Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients who are scheduled to undergo pancreticoduodenectomy or distal pancreatectomy or total pancreatectomy 2)No prior therapy of pancreatic surgery 3)Written informed consent. 4)Age of at least 20 years old at the time of registration. 5)Performance status of 0 or 1.
Exclusion criteria
Exclusion criteria: 1)Case with possibility of pregnancy or during nursing 2)Sever infection 3)Malabsorption syndrome without pancreatic disease 4)Alegyin porcine or bovine protein or digestive enzym 5)Participates in other examinations of pancreatic exocrine insufficiency. 6)The case judged to be inappropriate for the examination to carry out this study safely by attending doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increased level of serum albumin after treatment for 24 weeks compared with preoperative level. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)nutrient assessment 2)condition of stool 3)Body composition(%) 4)edema | — |
Countries
Japan
Contacts
Public ContactHideyuki Yoshitomi
Chiba University Hospital Hepatobiliary Pancreatic Surgery
Outcome results
None listed