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Toyama antihypertensive therapy with Olmesartan in Post-Stroke patients (TOPS) study

Toyama antihypertensive therapy with Olmesartan in Post-Stroke patients (TOPS) study - Toyama antihypertensive therapy with Olmesartan in Post-Stroke patients (TOPS) study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000009790
Enrollment
100
Registered
2013-01-20
Start date
2013-01-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension, Post-stroke

Interventions

Participants will be treated with 20mg olmesartan tablet once in the morning for 24 weeks.

Sponsors

University of Toyama
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Hypertensive patients with post stroke state (except cardiogenic embolism and subarachnoid hemorrhage) Outpatients 20 years old or older at the time of the informed consent

Exclusion criteria

Exclusion criteria: Myocardial infarction, cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, unknown type of stroke within previous 6 months (TIA can be registerd) Grade III hypertension (systolic BP>=180mmHg or diastolic BP>=110mmHg) Percutaneous or surgical coronary intervention (PCI, CABG etc.), severe heart failure within 6 months Percutaneous or surgical coronary intervention planned Persistent or permanent atrial fibrillation History of congenital heart disease, rheumatic heart disease, moderate or severe valvular heart disease Unstable angina, severe arrhythmia Pregnant, possible to pregnancy Not appropriate to long term observation Difficult to obtain consent because of minors or dementia etc.

Design outcomes

Primary

MeasureTime frame
Evaluation at 12 week and 24 week after 1) Blood pressure self-measured at home (home BP) in the early morning and evening, Morning/Evening ratio 2) Blood pressure at hospital (hospital BP) 3) The achievement rate of target blood pressures (at hospital and home)

Countries

Japan

Contacts

Public ContactNaoki Akioka

University of Toyama Department of Neurosurgery

akioka@med.u-toyama.ac.jp076-434-7348

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026