Investigation of the neural basis of intrinsic motivation in schizophrenia using fMRI and NIRS

Investigation of the neural basis of intrinsic motivation in schizophrenia using fMRI and NIRS - Neural basis of intrinsic motivation in schizophrenia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000009781

Enrollment

Registered

2013-01-21

Start date

2013-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Fifteen patients with schizophrenia according to the DSM-IV criteria recruited from outpatients and inpatients of National Center Hospital, National Center of Neurology and Psychiatry (NCNP). All patients were 20-50 years old and had the capacity to give written informed consent. (2)Fifteen healthy controls aged 20-50 years old without any history of psychiatric and neurological illness, who consented to participate in the study

Exclusion criteria

Exclusion criteria: (1)Patients with the estimated IQ lower than 80 (by Japanese Adult Reading Test) (2)Patients with history of organic brain disorder, dementia, pervasive developmental disorder, or substance/alcohol dependence. (3)Patients with severe irritation that hindered them from being seated still during the experiment. (4)Patients for whom changes in medication were presumed to be necessary during the study

Design outcomes

Primary

Measure	Time frame
Brain activation data using fMRI and NIRS along with behavioral data obtained while patients are processing Stop watch/Watch stop (SW/WS) task, which was designed to invoke intrinsic motivation in patients with schizophrenia. JART-25 PANSS UPSA-B SLOF GAF IMI	—

Countries

Japan

Contacts

Public ContactKazuyoshi Takeda

National Center Hospital, National Center of Neurology and Psychiatry Department of Psychiatry

ktakeda@ncnp.go.jp042-341-2711

Outcome results