New assessment and neural basis of working memory impairment in schizophrenia

New assessment and neural basis of working memory impairment in schizophrenia - Assessment of working memory impairment in schizophrenia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000009776

Enrollment

Registered

2013-01-21

Start date

2013-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Twenty patients with schizophrenia according to the DSM-IV criteria recruited from outpatients and inpatients of National Center Hospital, National Center of Neurology and Psychiatry (NCNP). All patients were 20-60 years old and had the capacity to give written informed consent. (2)Twenty healthy controls aged 20-60 years old without any history of psychiatric and neurological illness, who consented to participate in the study

Exclusion criteria

Exclusion criteria: (1)Patients with the estimated IQ lower than 80 (by Japanese Adult Reading Test) (2)Patients with history of organic brain disorder, dementia, pervasive developmental disorder, or substance/alcohol dependence. (3)Patients with severe irritation that hindered them from being seated still during the experiment. (4)Patients for whom changes in medication were presumed to be necessary during the study

Design outcomes

Primary

Measure	Time frame
Association between brain activation and behavioral parameters using new delayed response task focused on central executive system and behavioral indices as below. PANSS BACS CSB JART-25	—

Countries

Japan

Contacts

Public ContactKazuyoshi Takeda

National Center Hospital, National Center of Neurology and Psychiatry Department of Psychiatry

ktakeda@ncnp.go.jp042-341-2711

Outcome results