renal anemia with chronic kidney disease not on dialysis
Conditions
Interventions
None listed
Sponsors
National Hospital Organization Kyoto Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with estimated glomerular filtration rate 10 and more mL/min/1.73 m2 in chronic kidney disease stage 3-5 2. Patients with hemoglobin level of <11 g/dL or receiving erythropoiesis stimulating agent 3. Outpatients at enrollment
Exclusion criteria
Exclusion criteria: 1. Patients with other than renal anemia, such as gastrointestinal bleeding or hematological disorders 2. Patients who need blood transfusion frequently 3. Patients with active cancer or cancer treatment within last 2 years 4. Transplant recipients and patients who have previously received long-term dialysis 5. Patients with liver cirrhosis 6. Patients with received interferon 7. Patients with human immunodeficiency virus infection 8. Patients with pregnancy and breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite renal outcome of chronic dialysis, kidney transplantation, and doubling time of serum creatinine level | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change of eGFR from enrollment 2. Death of any cause 3. Incidence of cardiovascular event [death of cardiovascular event, myocardial infarction, stroke, hospitalization with acute coronary syndrome, hospitalization with heart failure, history of intervention for cardiovascular events (percutaneous coronary intervention, coronary artery bypass graft, cerebrovascular treatment, intervention for artery of lower extremities, leg amputation)] 4. relation between hemoglobin level and the primary outcomes or the secondary outcomes 5. relation between type of ESA and the primary outcomes or the secondary outcomes 6. relation between type of ESA and hemoglobin level | — |
Countries
Japan
Contacts
Public ContactKensei Yahata
National Hospital Organization Kyoto Medical Center Department of Nephrology
Outcome results
None listed