Chronic kidney disease after kidney transplantation
Conditions
Interventions
Hb normal group Target Hb level 13g/dl with erythropoietin stimulating agents(ESA)
Hb subnormal group Target Hb level 11g/dl with or without erythropoietin stimulating agents(ESA)
Sponsors
Nagoya Daini Red Cross Hospital
Masuko Memorial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.More than 1 year after kidney transplantation 2.Stable kidney function for at least 3 months 3.eGFR of 15-50 ml/min/1.73m2 4.Hb level of 9.0-11.5 g/dl with or without ESA 5.Patients who give written informed consent
Exclusion criteria
Exclusion criteria: 1.Urine protein more than 1g/day 2.Deterionation of kidney function within the preceding 3 months 3.History of acute rejection within 3 months 4.Uncontrolled hypertension(systolic blood pressure>140,diastolic blood pressure>100) 5.Active or uncontrolled infection 6.Prior diagnosis of malignancy 7.Iron deficiency anemia 8.Hemorrhage diathesis 9.Hb<10g/dl with ESA 10.Pregnancy or lactation 11.History of myocardial infarctioin or angina pectoris 12.History of cerebral infarction with any symptom 13.Hypersensitivity reactions to ESA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between Hb normal group and Hb subnormal group in rate of decline in kidney function for 5 years | — |
Countries
Japan
Contacts
Public ContactMakoto Tsujita
Nagoya Daini Red Cross Hospital Transplant Surgery
Outcome results
None listed