Suppress the joint destruction in clinical remission patients who have active synovitis of ultrasonographic assessment by increasing the dose of methotrexate

Suppress the joint destruction in clinical remission patients who have active synovitis of ultrasonographic assessment by increasing the dose of methotrexate - SCRUM study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009535

Enrollment

120

Registered

2012-12-12

Start date

2012-04-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatoid arthritis

Interventions

We randomly assigned patients who have the positive joint of power Doppler signal by ultrasonography even in clinical remission to increase or stable the dose of MTX and observation . MTX increase gr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: RA patients fulfiling the American Rheumatology Association criteria 1987 and ACR/EULAR classification cliteria 2010. The patients who have stable remission and 28-joint disease activity score CRP (DAS28-CRP) <2.6 for at least 3 months.

Exclusion criteria

Exclusion criteria: Patients who can not use oral MTX due to side effects. Patients with other diseases that can affect the infllamation state. Patients who was deemed inappropriate by test doctor to participate in this study.

Design outcomes

Primary

Measure	Time frame
the change of X-ray from baseline in the van der Heijde-Sharp score at week 52	—

Secondary

Measure	Time frame
the change of X-ray from baseline in the van der Heijde-Sharp score at week 24 the change of power doppler signal from baseline in the van der Heijde-Sharp score at week 24and 52	—

Countries

Japan

Contacts

Public ContactTadashi Okano

Osaka City University Medical School Orthopedic Surgery

ma1sa3ru@med.osaka-cu.ac.jp0666453851

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026