healthy male and female
Conditions
Interventions
substrate cocktail, wash out, with atorvastatin, wash out, with grapefruit juice
Sponsors
Department of clinical pharmacokinetics, Kyushu University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The investigators must ensure that all subjects being considered meet the following inclusion criteria: 1) Japanese healthy male or female who is capable to understand and sign the informed consent 2) 20-45 years of age 3) BMI 17.6-26.4 4) good health as determined by physical examination, vital signs and laboratory tests.
Exclusion criteria
Exclusion criteria: The investigators must ensure that all subjects being considered meet the following exclusion criteria or conditions: 1) history of allergy to any drugs 2) medical attention within 2 months prior to participation 3) donation of 200 mL or more of blood within 4 weeks prior to participation, or donation of component blood within 2 weeks prior to participation 4) donation of 400 mL or more of blood within 12 (male) or 16 (female) weeks prior to participation 5) recent (past 4 months) participation in other clinical trial for investigational new chemical entity 6) history of drug abuse 7) alcohol abuse 8) lactose intolerance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PK profiles of rosuvastatin, celiprolol, salazosulfapyridine, sumatriptan, glibenclamide and atorvastatin | — |
Countries
Japan
Outcome results
None listed