irreversible pulpitis
Conditions
Interventions
transplantation of pulp stem cells with G-CSF
Sponsors
National Center for Geriatrics and Gerontology, Research Institute
Aichi Gakuin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients to whom the research plan has been explained orally and by a document, and from whom the consent of his or her participation has been obtained directly by a doccument without any compulsion 2) Outpatients 3) Patients who have irreversible pulpitis in the single root canal 4) Patients who have unnesessary and/or discarded teeth (including wisdom tooth, the surplus dislocated tooth, expendientry extracted tooth for orthodontic treatment without occlusion) which can supply pulp tissue 5) Patients who have enough residual healthy tooth structure over alveolar bone, confirming by a X ray micrograph, completely preventing microleakage in the root canal by resin partitions 6) Patients who have no tooth fracture detected by a X ray micrograph 7) Patients who have no periapical radiolucency
Exclusion criteria
Exclusion criteria: 1) patients who have a difficulty in collecting peripheral blood 2) patients who has infection, such as virus, bacteria, fungus or mycoplasma 3) cardiovascular disease patients 4) patients taking anticoagulants or antiplatelet agents 5) diabetes (more than HbA1c 6.1%) 6) osteoporosis 7) pregnant woman, expectant pregnant woman 8) patients who have a past history of allergy with any antimicrobial agent or local anesthetia 9) patients who have a difficulty in getting the consent, such as mentally retarded or mentally illness persons 10) persons to whom the principal investigator of the clinical trial in charge consider to be inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systemic finding oral manifestation extraction socket finding blood test blood chemistry examination Urine chemistry examination periapical swelling tenderness, percussion pain | — |
Secondary
| Measure | Time frame |
|---|---|
| electric pulp test radio lucency at the apex psychroalgia, pain to hot and cold, spontaneous pain, tenderness, percussion pain | — |
Countries
Japan
Contacts
Public ContactKoichiro Iohara
National Center for Geriatrics and Gerontoogy Department of Dental Rgenerative Medicine
Outcome results
None listed