Effect of BMI and body fat percentage on pharmacokinetics and analgesic effect of fentanyl after trasndermal fentanyl patch administration

Effect of BMI and body fat percentage on pharmacokinetics and analgesic effect of fentanyl after trasndermal fentanyl patch administration - Effect of obesity on PK and PD of fentanyl patch

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009346

Enrollment

Registered

2012-11-16

Start date

2012-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer-related pain

Interventions

Administration of fentanyl patch and blood sampling

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) cancer-related pain 2) inpatients or outpatients 3) prescribed blood sampling is acceptable 4) age 20 years or higher 5) gave written informed concent

Exclusion criteria

Exclusion criteria: 1) history of hypersensitivity to fentanyl patch 2) concomitant use of other opioids (except for rescue) 3) concomitant use of azole antifungi drugs or steroids pulse therapy 4) bone metastasis 5) palliative radiation therapy 6) sever liver disease (AST or ALT, 100 IU/L or higher) 7) sever kidney disease (BUN 25 mg/dl or higher, or serum creatinine 2.0 mg/dL or higher) 8) other situation that doctor decides

Design outcomes

Primary

Measure	Time frame
Relation ship between BMI and body fat percentatge, and dose and serum concentration of fentanyl	—

Countries

Japan

Contacts

Public ContactYoshimichi Sai

Kanazawa University Hospital Department of Pharmacy

sai-ys@staff.kanazawa-u.ac.jp

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026