Blood pharmacokinetic study on fine-granulated of Kracie hachimijiogan ryo extract in humans

Blood pharmacokinetic study on fine-granulated of Kracie hachimijiogan ryo extract in humans - Blood pharmacokinetic study on fine-granulated of Kracie hachimijiogan ryo extract

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009334

Enrollment

Registered

2012-11-15

Start date

2012-11-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

Administration of 6.0 g fine-granulated hachimijiogan ryo extract of Kracie with 220 ml of water, and 2 weeks afterward 220 mL standard decoction of hachimijiogan ryo . Administration of 220 mL stand

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy male volunteers between 20 and 65 years of age who have given informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who donated blood during the past four months 2. Those who are sturdy. 3. Those who are sensitive to the heat, liable to have a rush of blood to the head, and have ruddy face. 4. Those who suffer from extremely poor digestion. 5. Those who suffer from poor appetite, nausea, and/or vomiting. 6. Those who suffer from serious diseases of liver, kidney, heart, lung or blood. 7. Those who take supplements or vitamins on a regular basis. 8. Those who physicians in charge judge not to be appropriate for the study.

Design outcomes

Primary

Measure	Time frame
Pharmacokinetic parameters of Loganin, Paeoniflorin and their metabolites, and safety assessment of their fine-granulated extracts.	—

Countries

Japan

Contacts

Public ContactKei Hamazaki

Polyene Project , Ltd Dept of Clinical Science

keihama@med.u-toyama.ac.jp076-432-0876

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026