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Prospective study of Docetaxel combined with Bevacizumab in advanced or recurrent non-squamous non-small cell lung cancer patients unfit for platinum-doublet chemotherapy and exploratory biomarker analysis for predicting the effect with antiangiogenic therapy.(OLCAS-001)

Prospective study of Docetaxel combined with Bevacizumab in advanced or recurrent non-squamous non-small cell lung cancer patients unfit for platinum-doublet chemotherapy and exploratory biomarker analysis for predicting the effect with antiangiogenic therapy.(OLCAS-001) - Phase II study of Docetaxel plus Bevacizumab in non-squamous NSCLC patients unfit for platinum-doublet chemotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000009263
Enrollment
40
Registered
2012-11-05
Start date
2012-11-05
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-squamous non-small cell lung cancer

Interventions

docetaxel plus bevacizumab

Sponsors

Oita University Faculty of Medicine, Department of Medical Oncology & Hematology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)pathologically or cytologically confirmed non-squamous non-small lung cancer 2)patients with clinical stage IIIb/IV or recurrent post-operative status, unsuitable for curative therapy or recurrent 3)no prior chemotherapy 4)patients who have the measurable disease defined by RECIST v1.1 5)patients with ECOG PS 0-2 6)age 20 years or older 7)medically unfit for platinum-doublet chemotherapy 8)adequate organ functions 9)estimated survival of at least 3 months 10)with written informed consent

Exclusion criteria

Exclusion criteria: 1) with uncontrollable co-morbidities 2)with episode of hemoptysis 3)clinically unfit for bevacizumab containing chemotherapy 4)with severe allergy of the medication 5)with ineligible conditions judged by the attending physician

Design outcomes

Primary

MeasureTime frame
Progression free survival

Countries

Japan

Contacts

Public ContactMorinaga Ryotaro

Oita University Hospital Department of Medical Oncology

rmorinaga@oita-u.ac.jp097-586-6275

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026