Autosomal Dominant Polycystic Kidney Disease (ADPKD), Autosomal Dominant Polycystic Liver Disease (ADPLD).
Conditions
Interventions
Sponsors
Department of Urology, School of Medicine, Kyorin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient with ADPKD and ADPLD, who consent to the protocol. 2. eGFR >45 ml/min/1.73m2 3. Patient who satisfy one or more following conditions Liver volume >3000 ml Total kidney volume >1000 ml Two symptom score >3 or one symptom score >4
Exclusion criteria
Exclusion criteria: 1) Subjects who are unlikely to adequately comply with trial's procedure. 2) Pregnant or lactating woman. 3) Subjects with uncontrolled or severe diabetes. 4) Subjects with allergy to octreotide or chemicals with similar structure to octreotide. 5) Subjects with comorbidity which interfare clinical evaluation. 6) Subjects with gall bladder stone. 7) Subjects who have scheduled surgery during trial. 8) Subjects taking other experimental therapies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) vital signs, 2) adverse events, 3) laboratory data, 4) develpement of cholelithiasis | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change of liver and kidney volume measured with MRI (CT). 2) Change of QOL-related questionnaire score. | — |
Countries
Japan
Contacts
Public ContactEiji Higashihara
Kyorin University School of Medicine, Department of Urology
Outcome results
None listed