Conversion from TIVA technique to Desflurane anesthesia for long duration neurosurgery; assessment of recovery parameters

Conversion from TIVA technique to Desflurane anesthesia for long duration neurosurgery; assessment of recovery parameters - Conversion from TIVA technique to Desflurane anesthesia for long duration neurosurgery; assessment of recovery parameters

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009204

Enrollment

Registered

2012-10-31

Start date

2012-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurosurgery

Interventions

Control group patients will receive propofol till the end of surgery. Study group patients will be switched to desflurane from propofol.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Planned craniotomy patients. ASA PS 1-3. Estimated procedure time > 4 hr.

Exclusion criteria

Exclusion criteria: Malignant Hyperthermia. History of the problem of previous anesthesia. Contraindication for propofol and desflurane. Preoperative cognitive disorder. Required postoperative sedation. Unstable vital or emergent cases. Liver function(Child-Pugh classification of B and C) or renal function failure(CKD stage>3).

Design outcomes

Primary

Measure	Time frame
Duration time to the extubation after the end of anesthetics administration	—

Secondary

Measure	Time frame
Duration time to the eye opening after the end of anesthetics administration. Time to recover the orientation after the end of anesthetics administration. Preoperative and post operative Mini-Mental State Examination scores. Duration of intensive care unit stay. Intraoperative monitoring parameters after the switching form propofol to desflurane.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026