Safety and efficacy of tramadol in the treatment of refractory pain of interstitial cystitis: a double-blind, placebo-controlled, randomized prospective study

Safety and efficacy of tramadol in the treatment of refractory pain of interstitial cystitis: a double-blind, placebo-controlled, randomized prospective study - The effect of tramadol on interstitial cystitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009197

Enrollment

Registered

2012-11-01

Start date

2014-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

interstitial cystitis

Interventions

oral administration of Tramadol after randomization oral administration of placebo after randomization

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: interstitial cystitis with refractory pain which is resistant to NSAIDs

Exclusion criteria

Exclusion criteria: 1) Patients with urinary tract infection 2) Case in which strong opioid has already been administrated 3) Patients with liver dysfunction 4) Patients with renal dysfunction 5) Pregnant women

Design outcomes

Primary

Measure	Time frame
Changes of pain scale after randomization	—

Secondary

Measure	Time frame
1 OLeary & Sant index 2 time to theraputic failure 3 OABSS 4 CLSS 5 IPSS 6 GRA 7 frequent voiding chart	—

Countries

Japan

Contacts

Public ContactAya Niimi

The University of Tokyo Hospital Department of Urology

niimia-uro@h.u-tokyo.ac.jp0338155411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026