borderline resectable pancreatic cancer
Conditions
Interventions
neoadjuvant S-1 and concurrent radiotherapy
Sponsors
JASPAC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) adenocarcinoma or adenosquamous carcinoma 2) no distant metastasis 3) borderline resectable pancreatic cancer 4) age 20-75 5) ECOG PS 0-1 6) No prior therapy 7) can be included in the irradiation field of 10cm x10cm 8) good oral intake 9) adequate biliary drainage for obstructive jaundice 10) no invasion to digestive tract 11) good main organ function 12) written informed consent
Exclusion criteria
Exclusion criteria: 1) no prior fluoropyrimidine anticancer therapy 2) prior abdominal radiotherapy 3) diarrhea 4) iodine contrast allergy 5) pulmonary fibrosis or interstitial pneumonitis 6) ascites or pleural effusion 7) active infection 8) poor controlled diabetes 9) active other malignancy 10) active digestive ulcer 11) serious complications 12) continuous steroid administration 13) severe mental disorder 14) pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| curative R0 resection rate | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival, recurrence free survival, response rate, pathological response rate, 2 year survival rate, adverse event, surgical complication, response rate based on the central radiological diagnosis | — |
Countries
Japan
Contacts
Public ContactIzumi Ohno
National Cancer Center Hospital East Division of Hepatobiliary and Pancreatic Oncology
Outcome results
None listed