Influence of aldehyde dehydrogenase2 genotype on peripheral vasodilation, nitrate tolerance and oxidative stress by organic nitrates: randomized crossover trial

Influence of aldehyde dehydrogenase2 genotype on peripheral vasodilation, nitrate tolerance and oxidative stress by organic nitrates: randomized crossover trial - Influence of aldehyde dehydrogenase2 genotype on the effects by organic nitrates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009105

Enrollment

Registered

2012-10-15

Start date

2012-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

angina pectoris

Interventions

nitroglycerin isosorbide dinitrate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Japanese healthy volunteers who are older than 20 and younger than 40

Exclusion criteria

Exclusion criteria: 1. History of cardiovascular disease 2. severe hepatic dysfunction 3. severe renal dysfunction 4. woman who is pregnant or possibly be pregnant 5. History of severe allergy or allergic reaction to nitroglycerin and isosorbide dinitrate 6. History of glaucoma 7. On medical treatment 8. On medical treatment of phosphodiesterase 5 9. Systolic blood pressure <90 mmHg 10. Body weight <40 kg or >90 kg 11. Not appropriate to this study by other reasons

Design outcomes

Primary

Measure	Time frame
Relation between aldehyde dehydrogenase 2 genotype and the changes of peripheral vasodilation, nitrate tolerance and oxidative stress after single and multiple administration of organic nitrates	—

Secondary

Measure	Time frame
Pulse rate, blood pressure and their post/pre-administration ratios Ratio of side effects by organic nitrate	—

Countries

Japan

Contacts

Public ContactTatsuya Yoshihara

Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology

tatsuya@clipharm.med.kyushu-u.ac.jp092-642-6082

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026