Evaluation of efficacy of diquafosol sodium ophthalmic solution and sodium hyaluronate ophthalmic solution on treatment of dry eye (multicenter study).

Evaluation of efficacy of diquafosol sodium ophthalmic solution and sodium hyaluronate ophthalmic solution on treatment of dry eye (multicenter study). - Evaluation of efficacy of diquafosol sodium ophthalmic solution and sodium hyaluronate ophthalmic solution on treatment of dry eye (multicenter study).

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009071

Enrollment

200

Registered

2012-11-01

Start date

2012-10-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye

Interventions

Diquafosol sodium ophthalmic solution Sodium hyaluronate ophthalmic solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) 20 years old or older. 2) female or male. 3) Schirmer test I below 5 mm in 5 minutes or BUT below 5 seconds. 4)General state score of symptoms is 4 greater, and degree score is 3 greater in at least more than 1 item within ophthalmic symptoms items. 5)Fluorescein staining score less than 3.

Exclusion criteria

Exclusion criteria: 1) Patients who use artificial tears eyedrops within 2 weeks before a study starts. 2) Patients who need to use eyedrops other than test drugs during a study . 3) Patients who have anatomically and functionally abnormal eyelid. 4) Patients who develop allergic conjunctivitis disease requiring treatment when a study starts. 5) Patients who underwent ophthalmic surgery within 3 months before study starts ( however LASIK within 6 months). 6) Patient who have a previous history of treatment intended to become obstructed lacrimal puncta. 7) Patients who have a previous allergy to drugs that they use during a study.

Design outcomes

Primary

Measure	Time frame
Symptoms and Tear film breakup time	—

Countries

Japan

Contacts

Public ContactAtsushi Shiraishi

Ehime University Department of Ophthalmology

shiraia@m.ehime-u.ac.jp089-960-5361

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026