Gastroesophageal reflux disease
Conditions
Interventions
esomeprazole20mg before meal twice a day at 08:00 and 22:00-wash out 2-4week-esomeprazole20mg before meal once a day at 08:00.-wash out 2-4week esomeprazole10mg before meal once a day at 08:00
esomepr
Sponsors
Division of Gastroenterology, Tohoku University Graduate Schooi of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. healthy volunteer 1. Subjects provide written voluntary consent to participate in the study after sufficient written and oral explanation.
Exclusion criteria
Exclusion criteria: 1. Subjects with past history of drug allergy 2. Subjects with hepatic, renal, or cardiac disorder 3. Subjects with a history of gastrectomy and/or vagotomy 4. Subjects who are on any treatment 5. Subjects who need to receive any drugs other thanthe study drug during the study. 6. Others as judged inappropriate by the investigator(s)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the rate of acid suppression at the steady state(at 14:00 on day7) among each group. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the rate of acid suppression of esomeprazole at 8:00 on day15* among each group. *at 8:00 on day15: Twenty-four hours after last administration for once daily and 10 hours after last administration for twice daily To evaluate the background factors that affect the acid suppression, such as H.pylori infecton, CYP2C19 polymophism in three groups. | — |
Countries
Japan
Contacts
Public ContactTomoyuki Koike
Tohoku University Graduate Schooi of Medicine Division of Gastroenterology
Outcome results
None listed