Low-dose Whole Brain Radiation Therapy combined with Stereotactic Radiosurgery for Brain Metastases: Multi-institutional Phase II study (JROSG13-1)

Low-dose Whole Brain Radiation Therapy combined with Stereotactic Radiosurgery for Brain Metastases: Multi-institutional Phase II study (JROSG13-1) - Low-dose Whole Brain Radiation Therapy combined with Stereotactic Radiosurgery for Brain Metastases: Multi-institutional Phase II study (JROSG13-1)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009055

Enrollment

Registered

2012-10-09

Start date

2012-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain metastases

Interventions

Low-dose whole brain radiotherapy (25 Gy in 10 fractions)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Age: 20-80 years old 2) Systemic status: KPS >= 70 3) Histopathologically confirmed 3) Indication for stereotactic irradiation (number of brain metastases, 4 or less, maximum tumor diameter, 3 cm of less) 5) Consent to neurocognitive fuctional tests and QOL questionnaire 6) Consent to this study

Exclusion criteria

Exclusion criteria: 1) severe decline in neurocognitive function or language ability at baseline 2) history of brain radiation therapy 3) history of brain surgery of brain metastases 4) small cell carcinoma, germinoma, lymphoma 5) any other reasons not to fit to this study

Design outcomes

Primary

Measure	Time frame
Development rate of distant brain metastases at 6-month after treatment	—

Secondary

Measure	Time frame
1) Neurocognitive function at 4-month 2) Neurocognitive function at 12-month 3) Local tumor control of brain metastases 4) Overall survival 5) Cause of death	—

Countries

Japan

Contacts

Public ContactHidefumi Aoyama

Niigata Univerisity Graduate School of Medical and Dental Sciences Radiology

jrosg13-1@med.niigata-u.ac.jp025-227-2315

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026