Effects of perioperative propofol infusion on energy expenditure, fat metabolism, protein catabolism and clinical courses following esophageal cancer surgery

Effects of perioperative propofol infusion on energy expenditure, fat metabolism, protein catabolism and clinical courses following esophageal cancer surgery - Comparison of two different anaesthesia/sedation techniques in esophageal cancer surgery : propofol anaesthesia/propofol sedation and sevoflurane anaesthesia/midazolam sedation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000009023

Enrollment

Registered

2012-10-03

Start date

2007-07-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

The patients are devided into two groups: propofol anaesthesia/propofol sedation group (Group PP, n = 10) or sevoflurane anaesthesia/midazolam sedation group (Group SM, n = 10). In Group PP, anaesth

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Male patients who undergo elective thoracoabdominal esophagectomy with gastric tube reconstruction starting at 9:00 a.m. and had performance status 0 are entered .

Exclusion criteria

Exclusion criteria: Preoperative exclusion criteria includes the patients who are obese (Body Mass Index > 30), have histories of diabetic mellitus, hyperlipidemia, liver dysfunction, renal dysfunction(Cr > 1.0), high-calorie infusion administration or chemoradiotherapy within 1 month before the day of surgery, or take medications of beta-adrenergic blocking agents, steroid agents or non-steroid anti-inflammatory drugs (NSAIDs). Postoperative exclusion criteria includes the patients who are in need of inspiratory oxygen fraction > 0.6 or positive end-expiratory pressure > 5 cmH2O during mechanical ventilation, dopamine > 3 microgram/kg/min, insulin, diuretic drugs, NSAIDs or beta-adrenergic blocking agents during intensive care unit stay.

Design outcomes

Primary

Measure	Time frame
The primary outcome is set to demonstrate that propofol has significant effects on energy expenditure, fat metabolism and protein catabolism.	—

Secondary

Measure	Time frame
Secondary outcome includes improvement in postoperative clinical courses by propofol.	—

Countries

Japan

Contacts

Public ContactRyuichi Nakanuno

Hiroshima University Hospital Department of Anesthesiology and Critical Care

nakanuno@hiroshima-u.ac.jp082-257-5267

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026