Prospective observational study about factors (genotyping of metabolic enzyme, sex and age etc) which influence the blood concentration of propofol during continuous infusion

Prospective observational study about factors (genotyping of metabolic enzyme, sex and age etc) which influence the blood concentration of propofol during continuous infusion - Study about the factors which influence the blood concentration of propofol during continuous infusion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000009015

Enrollment

100

Registered

2012-10-01

Start date

2012-10-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the patients undergoing a surgery by administration of propofol

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients who is undergoing surgery which will be longer than 4 hours at Kyushu University Hospital or Kyushu Medical Center 2.Use of target controlled propofol infusion pumps TE-371 (TERUMO, Japan) 3.Direct measurement of arterial pressure monitoring 4.Patients who can understand this study and give informed consent 5.Patients who are older than 20 years old

Exclusion criteria

Exclusion criteria: 1.Hemoglobin<10 g/dL 2.American Society of Anesthesiologists Physical Status class III or higher 3.Child-Pugh score class B and C 4.Estimate glomerular filtration rate < 60 mL/min/1.73 m2 5.Surgery of liver and kidney 6.Not appropriate to this study by other reasons

Design outcomes

Primary

Measure	Time frame
The relationship between the blood concentration of propofol and genetic polymorphism (UGT1A9 I399C>T, 5, CYP2B6 4, 5, 6 (G516T, A785G), 23, 26), age, sex, blood pressure, weight, body temperature and BIS values.	—

Countries

Japan

Contacts

Public ContactTatsuya Yoshihara

Faculty of Medicical Science, Kyushu University Department of Clinical Pharmacology

tatsuya@clipharm.med.kyushu-u.ac.jp092-642-6082

Outcome results