Living donor liver transplantation
Conditions
Interventions
The patients receive NIV for 2 to 3 hours in the daytime. Pressure support is increased until the maximal level tolerated by the patients is reached.
The patients continue the current treatments.
Sponsors
Department of respiratory management and sleep control medicine, Graduate School of Medicine, Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Recipients of living donor liver transplantation. 2. Analysis of arterial blood gas reveals PaO2 as less than 60 mmHg or PaCO2 as more than 7.3 or analysis of nocturnal monitoring reveals PtCO2 more than 45 mmHg or SpO2 less than 90%.
Exclusion criteria
Exclusion criteria: 1. recipients of emergency living donor liver transplantation 2. recipients of living donor liver retransplantation 3. Patients need to receive oxygen therapy or NIV therapy by analysis of arterial blood gas and nocturnal monitoring. 4. unstable asthma or mild chronic obstructive pulmonary disease (percent predicted FEV1) 5. pneumothorax within 6 months 6. patients complicated with chronic lung disease 7. patients complicated with acute infections. 8. patients received NIV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. arterial blood oxygen level 2. alveolar-arterial difference in partial pressure of oxygen | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. lung function testing (forced expiratory volume in one second (FEV1), FEV1/forced vital capacity, maximum mid-expiratory flow rate, respiratory muscle force) 2. preoperative chest X ray 3. postoperative arterial blood gas 4. postoperative pulmonary infection 5. postoperative death | — |
Countries
Japan
Contacts
Public ContactSatoshi Hamada
Graduate School of Medicine, Kyoto University Department of Respiratory Medicine
Outcome results
None listed