Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.

Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen. - Effects of ebastine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008951

Enrollment

Registered

2012-10-01

Start date

2012-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

allergic rhinitis

Interventions

Ebastine is administrated p.o. at a dose of 10mg to the subjects for 4 days and then the artificial exposure of Japanese cedar pollen at the concentration of 8000 counts/m3.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with allergic rhinitis to cedar pollen

Exclusion criteria

Exclusion criteria: 1) Patients who have ever suffered from adverse event of ebastine. 2) Patients who was excluded by investigators.

Design outcomes

Primary

Measure	Time frame
The expression of histamine H1 receptor and allergy-related cytokine mRNA in the nasal mucosa	—

Secondary

Measure	Time frame
The allergic rhinitis symptoms including sneezing, nasal discharge and nasal obstruction	—

Countries

Japan

Contacts

Public ContactYoshiaki Kitamura

University of Tokushima School of Medicine Department of Otolaryngology

ykitamura@tokushima-u.ac.jp088-633-7169

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026