The patients with nephrotic syndrome due to primary membranous nephropathy.
Conditions
Interventions
Treatment with a combination of mizoribine plus steroid therapy
Treatment with steroid monotherapy
Sponsors
The study group of treatment for aged patients with nephrotic syndrome.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient whose age is more than 65 years old, and who clears all of the following entry-criterion can enroll in this study. 1) The patient is established the diagnosis of nephrotic syndrome. 2) The diagnosis of membranous nephropathy is also histologically established. 3)The eGFR is more than 45ml/min.
Exclusion criteria
Exclusion criteria: Case that showed at least one of the following terms should be excluded. 1) Patient who have the allergy for mizoribine. 2) Data of WBC count before entry showed less than 3000/microL. 3) Patient who has the severe disease, such as heart and liver diseases. 4) Patient who has the severe bacterial, fungal or viral infection. 5) Patient who has the relapsed nephrotic syndrome. 6) Patient who experienced kidney transplantation. 7) The doctor decides that the patient is inappropriate to enroll in this study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1.Rate of continuity of the selected treatment. 2. The reduction of the degree of proteinuria. 3.Frequency of adverse complication derived from drug use. 4.Total dose of corticosteroid for treatment of nephrotic syndrome. 5. Changes in the renal function. | — |
Primary
| Measure | Time frame |
|---|---|
| Rate of remission from nephrotic syndrome | — |
Countries
Japan
Contacts
Public ContactHajime Hasegawa
The study group of treatment for aged patients with nephrotic syndrome. Affair
Outcome results
None listed