gastroesophageal reflux disease:GERD
Conditions
Interventions
None listed
Sponsors
Research Organization for GastroEnterological disease Treatment (ROGET)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The volunteers who do not have disorder would be influenced gastric acid secretion and who has provided written informed consent to participate in the study after full written and oral explanations.
Exclusion criteria
Exclusion criteria: Peptic ulcer History of gastrointestinal surgery (except for surgery for appendicitis and hemorrhoid) History of malignant tumor, renal failure, and other gastrointestinal diseases that may affect the study The use of drugs, including over-the-counter (OTC) drugs that affect gastric acid secretion (except for the as-needed use of drugs that can be discontinued from 2 weeks before gastric acid collection) History of H. pylori eradication The use of antithrombogenic drug The volunteer who is otherwise ineligible for the study in the investigator's opinion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure the basal acid output (BAO) and maximal acid output (MAO) separately in elderly (age 65 or over) and non-elderly subjects in each of the H. pylori-negative and H. pylori-positive groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| he following parameters will be measured and analyzed: Serum pepsinogen I and II levels Fasting serum gastrin levels Correlation between the fasting serum gastrin and the BAO/MAO Correlation between the serum pepsinogen and the BAO/MAO Gastric acid secretion in young subject (H. pylori-negative) Others | — |
Countries
Japan
Contacts
Public ContactYoshikazu Kinoshita
Shimane University School of Medicine Department of Gastroenterology and Hepatology
Outcome results
None listed