Patients scheduled for elective unilateral total knee arthroplasty under general anesthesia and peripheral nerve block
Conditions
Interventions
Postoperative continuous femoral infusion of ropivacaine 0.15% 4mL/h for 48 hours.
Postoperative continuous femoral infusion of levobupivacaine 0.1% 4mL/h for 48 hours.
Sponsors
Department of Anesthesia and Intensive Care Medicine, Osaka University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled unilateral total knee arthroplasty at Osaka University Medical Hospital 2.Adults (>=20 years) with American Society of Anaesthesiologists Physical Status Classification I-III 3.Participants were scheduled for primary unilateral TKA for osteoarthritis or rheumatoid arthritis 4.Written informed consent is provided
Exclusion criteria
Exclusion criteria: 1.Inability to communicate lucidly 2.Bilateral TKA 3.revision knee arthroplasty 4.Under 20 years old 5.Allergy to any of the drugs used in this study 6.ASA-PS > III 7.Chronic opioid use 8.Diabetes mellitus with sensory disorders 9.Neurological disability 10.Infections around femoral crease 11.Platelet < 5.0 * 10^4 /mcl 12.Pregnancy, possibility of pregnancy, or breast-feeding women 13.Contraindications to peripheral nerve blocks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the difference in maximum voluntary isometric contraction (MVIC) of the quadriceps 48 hours after surgery compared with the preoperative MVIC, expressed as a percentage of the preoperative MVIC. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints included postoperative knee range-of-motion, ambulatory ability, pain scores(Visual Analog Scale) at rest and during knee movement, and the consumption of additional analgesics. | — |
Countries
Japan
Contacts
Public ContactNorihiro Sakai
Osaka University Graduate School of Medicine Department of Anesthesia and Intensive Care Medicine
Outcome results
None listed