The effects of a DPP4 inhibitor on endothelial function in diabetic patients with coronary artery disease

The effects of a DPP4 inhibitor on endothelial function in diabetic patients with coronary artery disease - The effects of a DPP4 inhibitor on endothelium

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008806

Enrollment

Registered

2012-08-30

Start date

2011-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus with coronary artery disease

Interventions

Additional treatment of Sitagliptin conventional treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Type 2 diabetes mellitus (DM) patients with coronary artery disease 1. Uncontrolled DM patients with diet and exercise therapy 2. Uncontrolled DM patients treated with insulin injections or oral anti-diabetic drugs except DPP-4 inhibitors Patients with coronary artery disease documented by CAG or CT with organic coronary stenosis of >50% in major coronary arteries.

Exclusion criteria

Exclusion criteria: 1. Patients receiving GLP-1 receptor analogues injection and glinide drugs 2. Patients needed rapidly intensive glucose control 3. Patients with heart failure (New York Heart Association functional class II to IV) 4. Patients with active systemic inflammatory disease, chronic renal failure requiring hemodialysis, active hepatic disease, and presence of malignant tumor 5. Patients with acute coronary syndrome within 3 months preceding admission 6. Ineligible patients for any other reasons

Design outcomes

Primary

Measure	Time frame
Reactive hyperemia peripheral arterial tonometry index	—

Secondary

Measure	Time frame
High-sensitivity C-reactive Protein	—

Countries

Japan

Contacts

Public ContactJunichi Matsubara

Kumamoto University, Faculty of Life Sciences Department of Cardiovascular Medicine

j-matsu@kumamoto-u.ac.jp096-373-5175

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026