Effect of percutaneous transluminal angioplasty on endothelial function in patients with peripheral arterial disease

Effect of percutaneous transluminal angioplasty on endothelial function in patients with peripheral arterial disease - Effect of percutaneous transluminal angioplasty on endothelial function in patients with peripheral arterial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000008762

Enrollment

Registered

2012-09-01

Start date

2012-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral arterial disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with peripheral arterial disease who are scheduled for an elective percutaneous transluminal angioplasty. 2) Patients wituout peripheral arterial disease and coronary heart disease are enrolled as controls. 3) Patients who give informed consent.

Exclusion criteria

Exclusion criteria: 1) Patients who receive hemodialysis. 2) Patients who had received amputation of any lims. 3) Patients who are scheduled for a percutaneous transluminal angioplasty for the lesion below knee. 4) Patients who are scheduled for a percutaneous coronary intervention within a month. 5) Patients who had experienced acute coronary syndrome within 6 months. 6) Patients who have systemic inflammatory diseases including collagen diseases and infections. 7) Patients judged to be unsuitable participants by physician-in-charge.

Design outcomes

Primary

Measure	Time frame
1) Change of endothelial function by Endo-PAT 2) Change of circulating levels of myolines (Follistatin-like 1, IL-6, IL-7, IGF-1, FGF-2) 3) change of peripheral blood mononuclear cellprofileand numbers of endothelial progenitor cells and hematopoietic cells.	—

Secondary

Measure	Time frame
1) Fontaine classification 2) Ankle brachial index 3) Skin perfusion pressure 4) Body weight, body mass index, blood pressure, muscle mass of lower legs 5) hs CRP levels 6) Renal function and liver fuction tests	—

Countries

Japan

Contacts

Public ContactTetsuro Miyazaki

Juntendo University Hospital Department of Cardiovascular Medicine

03-3813-3111

Outcome results