An examination whether intermittent reinflation during one lung ventilation in lung resection would result in a time-dependent alteration of extravascular lung water

An examination whether intermittent reinflation during one lung ventilation in lung resection would result in a time-dependent alteration of extravascular lung water - Management of the nonventilated lung during one lung ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008759

Enrollment

Registered

2012-09-03

Start date

2003-12-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elective video-assisted thoracic surgery for lung tumor requiring one lung ventilation

Interventions

Patients are randomly assigned to either group C or group IR. Group C that is control group consists of patients whose nondependent lung is kept collapsed during OLV. Group IR that is intervention gro

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) ASA physical status I-II 2) elective video-assisted thoracic surgery for lung tumor requiring one lung ventilation lasting more than 120 minutes

Exclusion criteria

Exclusion criteria: 1) decompensated cardiac disease (> class II in New York Heart Association) 2) chronic pulmonary disease (vital capacity < 50% of predicted values and/or forced expiratory volume in 1 second < 50% of forced vital capacity) 3) chronic renal failure (serum creatinine > 1.5 mg/dl) 4) altered liver function (> class B in Child-Pugh) 5) preoperative treatment with immune modulator (cytostatic drugs, corticosteroids, nonsteroidal antiinflammatory drugs, vaccination, and blood products) within a month before surgery 6) pre-existing coagulation disorders 7) symptoms of an acute inflammatory process (clinically defined or abnormal data for C-reactive protein, leukocyte count, or body temperature) 8) Arteriosclerosis obliterans and/or iliac artery stenosis and/or aneurysms with or without bypass surgeries, which would be associated with an increased risk of complications following the femoral arterial cannulation for PiCCO

Design outcomes

Primary

Measure	Time frame
The primary outcome is set to the change of extravascular lung water with PiCCO (Pulsion Medical Systems, Munich, Germany) determined with the single indicator transpulmonary thermodilution technique at T1; baseline time after induction of anesthesia, T2; the end of the surgical procedure and before extubation, T3; just after the admission to the ICU, and T4; 12 hour after the admission to the ICU, respectively.	—

Measure

Time frame

The primary outcome is set to the change of extravascular lung water with PiCCO (Pulsion Medical Systems, Munich, Germany) determined with the single indicator transpulmonary thermodilution technique at T1; baseline time after induction of anesthesia, T2; the end of the surgical procedure and before extubation, T3; just after the admission to the ICU, and T4; 12 hour after the admission to the ICU, respectively.

—

Secondary

Measure	Time frame
Secondary outcome includes postoperative complications within 14 days and duration of postoperative hospitalization.	—

Countries

Japan

Contacts

Public ContactMasakazu YASUUJI

Hiroshima University Hospital Department of Anesthesiology and Critical Care

yasuuji@hiroshima-u.ac.jp082-257-5267

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026