Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease.

Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease. - Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008742

Enrollment

Registered

2012-08-21

Start date

2012-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moyamoya disease

Interventions

Administration of edaravone from preoperative to postoperative day 7.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with moyamoya disease scheduled for revascularization surgery in Hokkaido University Hospital.

Exclusion criteria

Exclusion criteria: Patients with serum creatinine level is greater than 1.5mg/dL. Patients with a history of hypersensitivity to edaravone. Patients determined to be ineligible to doctor due to a problem with the general condition.

Design outcomes

Primary

Measure	Time frame
The incidence of the hyper-perfusion syndrome within 7 days after the revasucularization surgery.	—

Secondary

Measure	Time frame
The incidence of asymptomatic hyper-perfusion on the cerebral blood flow image within 7 days after the revascularization surgery.	—

Countries

Japan

Contacts

Public ContactNaoki Nakayama

Hokkaido University Hospital Department of Neurosurgery

naoki-na@med.hokudai.ac.jp011-706-5987

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026