Significance of respiratory microbes in acute exacerbation of chronic obstructive pulmonary disease(COPD) and bronchial asthema detected by the comprehensive realtime PCR method

Significance of respiratory microbes in acute exacerbation of chronic obstructive pulmonary disease(COPD) and bronchial asthema detected by the comprehensive realtime PCR method - Significance of respiratory microbes in acute exacerbation of chronic obstructive pulmonary disease(COPD) and bronchial asthema detected by the comprehensive realtime PCR method

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000008731

Enrollment

200

Registered

2012-09-01

Start date

2012-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute exacerbation of a chronic airway inflammation disease(COPD/bronchial asthma)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.The adult patient who is diagnosed as COPD/bronchial asthma(BA) 2.The patient who is diagnosed as acute exacerbation of COPD BA due to acute respiratory symptoms,such as fever, sputum and dyspnea. 3.Within than seven days from the onset. 4.No previously prescribed any antimicrobial agent other than macrolide. 5.Agree with the informed and consent of this study.

Exclusion criteria

Exclusion criteria: 1.It has passed more than seven days from the onset. 2.Taking of antimicrobial agents other than macrolide 3.Disagree with the informed and consent of this study

Design outcomes

Primary

Measure	Time frame
1.Detection of 18 sorts of respiratory microbes(six sorts of bacteria,12 sorts of viruses)is done by a comprehensive genetic detection method among the acute exacerbation of two chronic airway inflammation diseases(COPD/bronchial asthma)of adult. We would show the pathogenic microbe which is related to acute exacerbation,and then the medical treatment strategy about acute exacerbation of these chronic airway inflammation disease based on these analysis results. 2.In addition, clinical isolation of M. pneumonia and antimicrobial susceptibility testing among culture positive cases is tried, although the macrolide-resistant strains increasing in recent years. And we would show the antimicrobial recommendation of M. pneumoniae.	—

Measure

Time frame

1.Detection of 18 sorts of respiratory microbes(six sorts of bacteria,12 sorts of viruses)is done by a comprehensive genetic detection method among the acute exacerbation of two chronic airway inflammation diseases(COPD/bronchial asthma)of adult. We would show the pathogenic microbe which is related to acute exacerbation,and then the medical treatment strategy about acute exacerbation of these chronic airway inflammation disease based on these analysis results. 2.In addition, clinical isolation of M. pneumonia and antimicrobial susceptibility testing among culture positive cases is tried, although the macrolide-resistant strains increasing in recent years. And we would show the antimicrobial recommendation of M. pneumoniae.

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Countries

Japan

Contacts

Public ContactKenichiro Shimizu

Jikei University School of Medicine Respiratory medicine

kennet29jp@yahoo.co.jp03-3433-1111(3271-2)

Outcome results