Analgesic effect and plasma ropivacaine concentrations after ultrasound-guided peripheral nerve block and postoperative continuous wound infusion in patients undergoing gynecological laparotomy

Analgesic effect and plasma ropivacaine concentrations after ultrasound-guided peripheral nerve block and postoperative continuous wound infusion in patients undergoing gynecological laparotomy - Analgesic effect and plasma ropivacaine concentrations after ultrasound-guided peripheral nerve block and postoperative continuous wound infusion in patients undergoing gynecological laparotomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008697

Enrollment

Registered

2012-08-15

Start date

2012-08-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients scheduled for gynecological laparotomy under general anesthesia

Interventions

Patients will receive ultrasound-guided peripheral nerve block with 0.3mg/kg of ropivacaine diluted 60ml under general anesthesia and laparotomy will be performed.They will receive analgesia through

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.female patients(American Society of Anesthesiologists physical status 1 to 3) undergoing gynecologic laparotomy at Sumitomo hospital 2.Written informed consent is provided

Exclusion criteria

Exclusion criteria: 1.over ASA-PS4 2.epidural anesthesia 3.laparoscopic surgery 4.allergy in ropivacaine

Design outcomes

Primary

Measure	Time frame
Visual analog scale (VAS) at rest and at mobilization, assessed at 3, 24,48 and 72hours after surgery	—

Secondary

Measure	Time frame
1.Plasma ropivacaine concentarations before and 16, 40 and 64hours after starting continuous wound infusion 2.Time to independent ambulations 3.Consumption of rescue analgesia at 24,48,72hours after surgery 4.Incidence of nausea and vomitting 5.Ocurrence of local anesthetic intoxication by ropivacaine 6.Ocurrence of adverse effects by cathters placed into the wound	—

Countries

Japan

Contacts

Public ContactAi Nakamoto

Sumitomo Hospital Department of Anesthesia

nakamoto-ai@sumitomo-hp.or.jp06-6443-1261

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026