Exploratory study on efficacy and safety of [11C]ketoprofen methylester in mild Alzheimer's disease, mild cognitive impairment and healthy volunteers.

Exploratory study on efficacy and safety of [11C]ketoprofen methylester in mild Alzheimer's disease, mild cognitive impairment and healthy volunteers. - KET-2

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008674

Enrollment

Registered

2012-08-13

Start date

2012-08-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer&#39

Interventions

PET imaging with [11C]PiB and [11C]ketoprofen methylester

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy or diagnosed as mild Alzheimer's disease or mild cognitive impairment based on history, physical examination, blood test, MRI, and neuropsychological tests including MMSE, LMII, GDS, CDR and MoCA-J for all subjects and some additional tests for patients.

Exclusion criteria

Exclusion criteria: Peptic ulcer. Cerebrovascular disorder. Heart failure. Disease in blood, liver or kidney. Drug or food allergy. Possibility of pregnancy. MRI contraindication. Those judged by the investigator to be inappropriate as a participant of this study.

Design outcomes

Primary

Measure	Time frame
Safety, Brain PET image	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Exploratory study on efficacy and safety of [11C]ketoprofen methylester in mild Alzheimer&#39;s disease, mild cognitive impairment and healthy volunteers.