A research of exploring possible predictive biomarkers for remission and recovery in ultra-high-risk individuals and first-episode psychosis

A research of exploring possible predictive biomarkers for remission and recovery in ultra-high-risk individuals and first-episode psychosis - Integrative Neuroimaging studies in Schizophrenia Targetting for Early intervention and Prevention (IN-STEP) project.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000008660

Enrollment

200

Registered

2012-08-10

Start date

2008-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ultra-high-risk for psychosis (UHR) and first-episode psychosis (FEP).

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. No history of antipsychotic drug treatments for more than 16 cumulative weeks 2. Continuous psychotic symptoms within the past 60 months

Exclusion criteria

Exclusion criteria: 1. More than 31 years old in UHR group 2. Neurological illness 3. Previous traumatic brain injury with any known cognitive consequences or loss of consciousness for more than 5 min 4. A history of electroconvulsive therapy 5. Low premorbid IQ (below 70) 6. Previous alcohol addiction 7. Previous continuous substance use 8. Clearly diagnosed with autistic disorder according to the DSM-IV criteria

Design outcomes

Primary

Measure	Time frame
The rate of transition to psychosis.	—

Secondary

Measure	Time frame
The rate of symptomatic remission and social recovery.	—

Countries

Japan

Contacts

Public ContactShinsuke Koike

The University of Tokyo Department of Neuropsychiatry, Graduate School of Medicine

skoike-tky@umin.ac.jp+81-3-5800-9263

Outcome results