Surgical cases of brain tumor treated with antiepileptic drugs (AEDs)
Conditions
Interventions
Levetiracetam
Zonisamide
Sponsors
Department of Neurosurgery, Kyoto University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Any surgical adult case of supratentorial brain tumor, who needs antiepileptic treatment due to past history of seizure and/or abnormal findings on electroencephalography, will be included based on his/her informed consent
Exclusion criteria
Exclusion criteria: The patient, who is on pregnancy and lactation period, with severely impaired liver function, with renal dysfunction (CCre<50), who needs two or more antiepileptic drugs for seizure control, who has more than one generalized seizure a day, who has past history of interstitial irradiation, who has life expectancy less than six months, who cannot take oral medication, who has Karnofsky Performance Score <70, who has hypersensitivity to the designated medicine and/or pyrrolidone derivative, who disagree with this research, who has brain tumor only in the posterior fossa, or who does not have surgical indication for tumor, will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure control, up to 6 months after surgical treatment Incidence of unacceptable adverse events | — |
Countries
Japan
Contacts
Public ContactTakayuki Kikuchi
Kyoto University Hospital Department of Neurosurgery
Outcome results
None listed