anaplastic thyroid cancer
Conditions
Interventions
Chemotherapy with weekly paclitaxel administration. 80mg/m2 once every week. One course consisted of 3 administrations. At least 1 course of the therapy is necessary. Therapy may continue when availab
Sponsors
Anaplastic Thyroid Carcinoma Consortium Japan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient who fulfills all following criterion. (1) pathologically proven anaplastic thyroid cancer (2) aged 20 and over (3) ECOG performance status 0-2 (4) suffient organ function(e.g. marrow,liver, kidney,bone) (5) written informed consent
Exclusion criteria
Exclusion criteria: Patient who matches one of these criterion. (1) suspision for interstitial pneumonia or pulmonary fibrosis by chest radiograph (2) brain metastasis with symptom (3) presence of the active peptic ulcer (4) presence of the active other malignancies (5) fever more than 38C (6) severe complication (e.g. myocardial infarction within 3 months, heart failure with clinically problem, poorly controlled diabetes mellitus, severe infectious disease. (7) past history for severe drug allergy (8) past history of hypersisitivity to polyoxyethylated or hydrogenated castor oil (9) hypersisitivity to alcohol (10) pregnant or nursing women (11) difficult to entry due to psychological problem (12) previous chemotherapy or radiation therapy to the present illness (13) physician judged improper to entry this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative dose intensity and safety of the chemotherapy will be evaluated. Overall response rate, time to failure, type of recurrence, overall survival. | — |
Countries
Japan
Contacts
Public ContactIwao Sugitani
Anaplastic Thyroid Carcinoma Consortium Japan Department of Endocrine Surgery, Nippon Medical School
Outcome results
None listed