Prospective controlled trial of piperacillin versus ampicillin for lower respiratory infection caused by Haemophilus influenzae

Prospective controlled trial of piperacillin versus ampicillin for lower respiratory infection caused by Haemophilus influenzae - Controlled trial of PIPC vs ABPC for Hi Bronchitis/Pnerumonia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008561

Enrollment

100

Registered

2012-08-01

Start date

2012-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute bronchitis/pneumoniae caused by Haemophilus influenzae

Interventions

Piperacillin 100mg/kg divided to 3 times per day, intravenous. Ampicillin 100mg/kg divided to 3 times per day, intravenous.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The lower airway infection patient by whom the gram negative bacteria considered to be Haemophilus influenzae were detected at predominance by the Gram's stain of sputum.

Exclusion criteria

Exclusion criteria: The case considered that the medical treatment by a penicillin system antimicrobial drug independent is unsuitable since it is in critical states, such as acute respiratory failure and a septic shock

Design outcomes

Primary

Measure	Time frame
Alleviation of fever. Calming of respiratory tract condition. Reduced frequency of antimicrobial resistant bacteriae(especially beta lactamase non-producing ampicillin resistant H.influenzae:BLNAR).	—

Countries

Japan

Contacts

Public ContactABE Katsuaki

Chiba Kaihin municipal hospital Pediatrics

043-277-7711

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026