Exploratory research of the effect of single dose of medication on the motor cortical excitability induced by repetitive transcranial magnetic stimulation in healthy volunteers

Exploratory research of the effect of single dose of medication on the motor cortical excitability induced by repetitive transcranial magnetic stimulation in healthy volunteers - Effects of single dose medicine on cortical excitability

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008508

Enrollment

Registered

2012-08-01

Start date

2012-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Effects of single dose LDOPA/Carbidopa or zonisamide on neural plasticity Participants come three times separated by 1-4 weeks and are assigned to one medicine randomly chosen among LDOPA/Carbidopa,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adult volunteers from whom we obtained informed consent

Exclusion criteria

Exclusion criteria: In case of gastric ulcer, duodenum ulcer, internal metal such as cardiac pace maker, drug delivery pump or DBS, severe cardiac disease, hepatic disease, renal disease, pulmonary disease, ileus, bronchial asthma, uncontrolled diabetic mellitus, chronic open angle glaucoma, cerebral stroke, brain injury, brain tumor, epilepsy, psychiatric disorder, pregnant females, or those contemplating pregnancy. And people whom the investigators evaluate as approved.

Design outcomes

Primary

Measure	Time frame
Amplitude of the motor evoked potentials(MEP)	—

Countries

Japan

Contacts

Public ContactRitsuko Hanajima

University of Tokyo Hospital Neurology

hanajima-tky@umin.ac.jp03-3815-5411

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026