lymphatic malformation
Conditions
Interventions
Sponsors
University of Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)They are diagnosed as a lymphatic malformation. 2)They have symptoms of bleeding or pain. 3)They have no indication of surgical treatment and sclerotherapy.
Exclusion criteria
Exclusion criteria: 1) Heart disease 2) Hypotension (Systolic blood pressure < 70mmHg) 3) Bradycardia (Pulse rate <60/min) 4) Asthma 5) Diabetic ketoacidosis,metabolic acidosis 6)idiopathic hypoglycemia,uncontroled diabetes (Blood suger < 60mg/dl) 7)fasted state over one month 8)peripheral circulatory disturbance 9)untreated phenochromocytoma 10)administration of thioridazine 11)administration of rizatriptan benzoate 12)oral use of antihypertensive agent 13)oral use or local injection of adrenal cortical steroid 14)Patient who was considered ineligible by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding and pain | — |
Secondary
| Measure | Time frame |
|---|---|
| (Reduction ratio) Measured by MRI and echo images of lymphatic malformation (Other) Changes in the lymphoid follicles (Safety endpoints) Bradycardia, hypotension, drowsiness, insomnia, rash, diarrhea, difficulty breathing, wheezing, decreased blood glucose | — |
Countries
Japan
Contacts
Public ContactMitsunaga Narushima
University of Tokyo plastic and reconstructive surgery
Outcome results
None listed