Parkinson disease
Conditions
Interventions
Selegiline hydrochloride 5mg 8weeks, 7.5mg 8weeks and stop it, followed after 8weeks, and evaluate each points.
Sponsors
Department of Neurology, Juntendo Koshigaya Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed as Parkinson' s disease and classified into Modified Hohen & Yahr staging Scale I through 2) Patients whose symptom of posture disorder is latent in supine position 3) Patients aged 20 or over when their consents given 4) Hospitalized patients/outpatients
Exclusion criteria
Exclusion criteria: 1) Patients receiving drugs prohibited for concomitant 2) Patients who have lumber spine deformation evaluated by an X-ray examination 3) Patients whit orthostatic hypotension 4) Patients receiving medical treatment for epilepsy 5) Patient who have symptoms of serious nerve and / or psychiatric disorders such as disturbance of consciousness , hallucination , delusions and abnormal behavior 6) Patient with severs disease of heart , blood vessels , liver , renal , blood and other life-threatening diseases 7) Patients who have or had schizophrenia 8) Patients who have or had addiction to central nerve system stimulants such as cocaine 9) Patients who are pregnant during the period of study 10) Patients addiction to alcohol or drugs 11) Patients who are determined as unfit for the study by attending physicians for reasons other than those stated above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rsults of stabilometry (Gravicoder GS-3000; AeNIMA) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Modified Hoehn & Yahr stage of Parkinson's Disease 2. Iapanese version, UPDRS Part I, Part II, Part III, Part IV 3. Degree of posture flexion (degree of antero flexion/ degree of side flexion) using photo. 4. Pain evaluation with VAS scale. 5. Safety evaluation, side effects. | — |
Countries
Japan
Contacts
Public ContactAsako Yoritaka
Juntendo Koshigaya Hospital Neurology
Outcome results
None listed