Antidepressant efficacy and mechanism of add-on cognitive activation to repetitive transcranial magnetic stimulation in depression

Antidepressant efficacy and mechanism of add-on cognitive activation to repetitive transcranial magnetic stimulation in depression - Cognition-engineered anhancement of rACC activity in boostering antidepressant efficacy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008421

Enrollment

Registered

2012-07-12

Start date

2011-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A randomized sham-controlled study

Interventions

Cognition demanding tests for 10 minutes before active rTMS treatment Non-cognition demanding tests for 10 mins before active rTMS treatment Cognition demanding tests for 10 minutes before sham rTMS

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: DSM-IV Major depressive disorders, recurrent Refractory to at least 2 adequate trials of antidepressant treatments (including one SSRI)

Exclusion criteria

Exclusion criteria: Major systemic, neurological illness Substance abuse Personality disorders OCD PTSD Major psychotic disorders(e.g., Schizophrenia)

Design outcomes

Primary

Measure	Time frame
EEG-theta (esp. frontal regions) PET-glucose metabolism: ACC and PFC Antidepressant efficacy (HAMD-17 scores)	—

Countries

Asia(except Japan)

Contacts

Public ContactCheng-Ta Li

Taipei Veterans General Hospital Psychiatry

on5083@msn.com+81-1886228757027

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026