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Biological effects of oral antimicrobial on systemic bacterial infection caused by full-mouth scaling and root planning: a randomized controlled clinical trial

Biological effects of oral antimicrobial on systemic bacterial infection caused by full-mouth scaling and root planning: a randomized controlled clinical trial - Biological effects of oral antimicrobial on systemic bacterial infection secondary to FM-SRP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000008411
Enrollment
60
Registered
2012-07-12
Start date
2012-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe chronic periodontitis

Interventions

Test group 1. 30 patients 2. Patients take 2g of test drug, 3 days before full-mouth scaling and root planning. Control group 1. 30 patients 2. Patients receive full-mouth scaling and root plann

Sponsors

Niigata University
Lead Sponsor
Department of Periodontology, Tokyo Medical And Dental University Department of Periodontics, Tsurumi University Bunkyo do-ri Dental Clinic Yoshino Dental Office Perio Implant Center
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Moderate to severe chronic periodontitis patients over the age of 30 years 2. Possessed a minimum of 20 teeth 3. Having at least 12 teeth with probing pocket depth (PPD) greater than 5 mm in a full-mouth.

Exclusion criteria

Exclusion criteria: 1. Persons who had received scaling and root planing within the previous 6 months. 2. Persons who had taken systemic antibiotics or anti-inflammatory drugs within 3 months before experiment. 3. Persons who had severe systemic diseases. 4. Persons who is known or suspected hypersensitivity or intolerance to macrolide antibiotic. 5. Smoker 6. Persons who is suspected of having aggressive periodontitis.

Design outcomes

Primary

MeasureTime frame
Cytokine expression level in serum—

Secondary

MeasureTime frame
Blood endotoxin level Cytokine expression level in gingival crevicular fluid—

Countries

Japan

Contacts

Public ContactToshiya Morozumi

Niigata University Medical & Dental Hospital Department of Periodontics

moro@dent.niigata-u.ac.jp0252272871

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026