Research on the comparison of effect between hormone replacement therapy and keishibukuryogan for patients with climacteric syndrome and relation with the estrogen receptor in the effect

Research on the comparison of effect between hormone replacement therapy and keishibukuryogan for patients with climacteric syndrome and relation with the estrogen receptor in the effect - The effects of hormone replacement therapy and Keishibukuryogan for climacteric syndrome according to relation to estrogen receptor

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008387

Enrollment

100

Registered

2012-07-09

Start date

2009-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

climacteric syndrome

Interventions

Keishibukuryogan Hormone replacement therapy

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Positive in Kupperman index 2) Menses was delayed more than one month within the past year, or shorter than 25 days. 3) Hormone value: FSH is equal or more than 20 mIU / ml or anti-mullerian hormone is abnormal value.

Exclusion criteria

Exclusion criteria: 1. Patients in the history of surgery of the ovaries or uterus 2. Patients with hypothyroidism and hyperthyroidism 3. Patients taking drugs of vasodilator 4. Patients with prohibition of estrogen (estrogen-dependent tumor, breast cancer, pregnant woman, serious liver damage, suspicious thrombosis and genital bleeding)

Design outcomes

Primary

Measure	Time frame
Improvement of Kupperman menopausal index	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026