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Blood pressure lowering effect of one compound tablet replacement as two tablets of angiotensin 2 receptor blocker(ARB) and calcium channel blocker(CCB)

Blood pressure lowering effect of one compound tablet replacement as two tablets of angiotensin 2 receptor blocker(ARB) and calcium channel blocker(CCB) - ECO Tablet trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000008360
Enrollment
200
Registered
2012-08-01
Start date
2012-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the hypertensive patient who has taken ARB and CCB

Interventions

To the hypertensive patient who has taken azelnidipine 16mg/day and olmesartan 20mg/day, or amlodipine 5mg/day and olmesartan 20mg/day, respectively, more than one month (4 weeks), we replace one co

Sponsors

Department of Cardiovascular Medicine, Okayama Univesity Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: a) the hypertensive patient who has taken azelnidipine 16mg/day and olmesartan 20mg/day, or amlodipine 5mg/day and olmesartan 20mg/day, respectively, more than one month (4 weeks). b)the patient whose blood pressure at a mediacl office is below 159/99mmHg. c)the patinet above 20 years-old.

Exclusion criteria

Exclusion criteria: a) patient with previous allergic reaction to azelnidipine or olmesartan. b) female patient who has possibility of pregnancy. c) patient treated with azole antifungal drug or HIV protease inhibitor. d) patient who has taken hemodialysis or has severe renal dysfunction (serume creatine level is above 2.0mg/dL). e) patient considered to be improper to this study by attending doctor.

Design outcomes

Primary

MeasureTime frame
change of systolic blood pressure at a medical office

Secondary

MeasureTime frame
change of diastololic blood pressure at a medical office, blood presssure at home, compliance of drug

Countries

Japan

Contacts

Public ContactKunihisa Kohno

Okayama Univesity Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Cardiovascular Medicine

kunihisakohno@msn.com086-235-7351

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026