rosacea
Conditions
Interventions
The similar eruptions of rosacea on both sides of the face are chosen as the treatment lesions. 0.2% rapamycin ointment is applied on the skin lesion on the right, and the ointment base or the ointm
Sponsors
Department of Dermatology Graduate School of Medicine, Osaka University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with rosacea who come to our outpatient department. 2) Patients who are resistant to previous treatment. 3) Patients who want to receive the treatment with the rapamycin ointment. 4) Patients who have not received topical steroid treatment for more than 2 months in the previous year.
Exclusion criteria
Exclusion criteria: 1) Patients who cannot comply with the treatment plan. 2) Patients who are allergic to macrolide antibiotics. 3) Patients who received oral administration of rapamycin or RAD001 within six months prior to the study entry. 4) Patients who received oral administration of macrolide antibiotics for more than 7 days within three months prior to the study entry. 5) Patients who received topical steroid treatment within three months prior to the study entry. 6) Patients who received topical treatment of tacrolimus, nadifloxacin, clindamycin or adapalene within a month prior to the study entry. 7) Patients who have a large wound or scar on the face, which would interfere the treatment or the assessment. 8) Patients who are pregnant or lactating. 9) Patients under 18 years of age. 10) Patients who were judged unsuitable for this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in redness and size of eruptions after 4 and 8 weeks of treatment, and at 4 and 8 weeks after end of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Appearance of contact dermatitis Rapamycin levels in whole blood histological findings in specimens of skin tissue in the cases who agree with skin biopsy | — |
Countries
Japan
Contacts
Public ContactMari Wataya-Kaneda
Graduate School of Medicine, Osaka University Department of Dermatology
Outcome results
None listed