Evaluation of efficacy and safety of rebamipide ophthalmic solution for dry eye after surgery of Diabetic Retinopathy

Evaluation of efficacy and safety of rebamipide ophthalmic solution for dry eye after surgery of Diabetic Retinopathy - Efficacy of rebamipide for dry eye after surgery of Diabetic Retinopathy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008308

Enrollment

Registered

2012-07-01

Start date

2012-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with dry eye after surgery of Diabetic Retinopathy

Interventions

Rebamipide ophthalmic solution hyaluronic acid ophthalmic solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patient scheduled for surgery of Diabetic Retinopathy 2) Patient who have symptom of dry eye (foreign body, drying, glaring, pain, blurring, eyestrain) 3) Patient who meet following conditions, a) Positive vital dye staining of cornea (Fluorescein, more than 3, maximum=9) b) Schirmer test (I) <= 5mm or Tear film breakup time <= 5 seconds

Exclusion criteria

Exclusion criteria: 1) Patient who do not consent with this study 2) Patient who is considered to be inappropriate for this study (patient who have high risc ocular disorder like Stevens-Johnson syndrome , women under pregnant or lactation period , allergic history to test drug)

Design outcomes

Primary

Measure	Time frame
Fluorescein corneal staining score	—

Secondary

Measure	Time frame
Tear film breakup time, Schirmer test(I), Questionnaire, Aqueous flare	—

Countries

Japan

Contacts

Public ContactYoshinori Mitamura

Tokushima University Hospital Ophthalmology

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026