Hypercholesterolemia with carotid artery plaque
Conditions
Interventions
Pitavastatin will be administered for 6 months at a dosage of 1~4 mg/day.
Sponsors
Ehime University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)The patient who observed the plaque in the carotid artery by MRI(Not less than 50% of the degree of stenosis). 2)The patient who is going not to perform CAS and CEA etc. but to perform Follow up. 3)At the time of entry, pitavastatin is not taken. 4)Patients with hypercholesterolemia. 5)Patients aged 20 years or older at the time of giving consent. 6)Patients giving written consent after being provided with sufficient explanation about participation in this clinical trial.
Exclusion criteria
Exclusion criteria: 1)At the time of entry, pitavastatin is taken. 2)The patient who had enforced CAS in the past to the carotid artery plaque lesion which evaluates. 3)Patients who have hypersensitivity to LIVALO tablet. 4)Patients who are being treated with cyclosporine. 5)Patients who have liver dysfunction The following patients considered that biliary obstruction or liver metabolism ability is falling(acute hepatitis, Acute aggravation of chronic hepatitis, hepatic cirrhosis, hepatoma, jaundice) 6)Pregnant women, women suspected of being pregnant, or lactating women 7)Patients who have renal dysfunction, or undergoing dialysis. 8)Patients who are ineligible in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qualitative and quantitative change of carotid artery plaque by carotid artery echo and MRI evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Change of serum lipids(TC,LDL-C,TG,HDL-C). 2)Incidence rate of event. 3)Change of hs-CRP and osteopontin. 4)Evaluation of carotid artery plaque by microbubble contrast material. 5)Evaluation of carotid artery plaque by contrast-enhanced CT. 6) Relationship of change of carotid artery plaque and serum lipids, blood marker. 7)Change of intracranial stenosis. | — |
Countries
Japan
Contacts
Public ContactYoshiaki Kumon
Ehime University Neurosurgery
Outcome results
None listed