Visceral fat and adipocytokine profile in Japanese patients with type2 diabetes mellitus treated with DPP-4 inhibitors.

Visceral fat and adipocytokine profile in Japanese patients with type2 diabetes mellitus treated with DPP-4 inhibitors. - DPP-4 inhibitors and visceral fat

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000008250

Enrollment

Registered

2012-07-01

Start date

2012-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

Alogliptin 25mg Pioglitazone 15mg-30mg Metformin 500mg-2250mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Type 2 diabetes patients, attending the OPD of the Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School hospital, insufficiently controlled (HbA1c (NGSP) less than 9%) with alimentary therapy or on alpha-glucosidase inhibitors and/or sulfonylurea.

Exclusion criteria

Exclusion criteria: 1) Patients who were added other OADs during the course of the trial. 2) Patients on corticodteroid. 3) Patients with renal impairment or moderate to severe hepatic dysfunction. 4) Patients with heart failure. 5) Patients treated with insulin or who absolutely needs insulin treatment. 6) Patients with current malignancy. 7) Patients with endocrine disorders. 8) Patients with severe mental illness. 9) Patients with pregnancy or lactating. 10) An excessive alcohol drunker. 11) Patients under the contraindication of each drugs.

Design outcomes

Primary

Measure	Time frame
Decrement of visceral fat area/ visceral fat/subcutaneous fat rate, Change in adipocytokine/PWV	—

Countries

Japan

Contacts

Public ContactMitsuru Hashiramoto

Kawasaki Medical School Hospital Division of Diabetes, Endocrinology and Metabolism

hashira@med.kawasaki-m.ac.jp086-462-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026