Impact of Endothelial Dysfunction on Residual Platelet Aggregability after Dual Anti-platelet Therapy with Aspirin and Clopidogrel in Stable Patients with Coronary Artery Disease

Impact of Endothelial Dysfunction on Residual Platelet Aggregability after Dual Anti-platelet Therapy with Aspirin and Clopidogrel in Stable Patients with Coronary Artery Disease - Endothelial Function in Dual Anti-platelet Therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000008239

Enrollment

100

Registered

2012-07-01

Start date

2008-08-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We first registered stable patients with CAD who were consulted to Kumamoto University Hospital. CAD was defined as the presence of angina history or myocardial ischemia by stress tests with the presence of coronary stenosis more than 50% of the vessel diameter detected by coronary angiography or computed tomography coronary angiography scan, or history of myocardial infarction, PCI, or coronary artery bypass grafting.

Exclusion criteria

Exclusion criteria: 1:acute coronary syndromes 2:known allergy to clopidogrel 3:thrombocytopenia 4:patients with collagen disease 5:infection 6:severe liver dysfunction 7:malignant diseases 8:patients were treated with ticlopidine, cilostazol and sarpogrelate 9:hemodialysis

Design outcomes

Primary

Measure	Time frame
endothelial function and residual platelet aggregability	—

Countries

Japan

Contacts

Public ContactKoichiro Fujisue

Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine

fujisues@kumamoto-u.ac.jp81-96-373-5175

Outcome results